An efficient labeling strategy of drug like molecules with functionalized alkyl linkers using CH-activation.
نویسندگان
چکیده
Heterocyclic drugs can be cross-coupled with functionalized thiophene derivatives under dehydrogenative conditions using Pd-catalysts. Upon reductive desulfurization an alkyl linker is introduced with a functional group at its terminus, which will allow the immobilization of the drug molecule onto a solid support for chemical proteomics.
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ورودعنوان ژورنال:
- Chemical communications
دوره 48 83 شماره
صفحات -
تاریخ انتشار 2012